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Scientific Publications & Posters
2009
x-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain
Authors: Andreas Brust, Elka Palant, Daniel E. Croker, Barbara Colless, Roger Drinkwater, Brad Patterson, Christina I. Schroeder, David Wilson, Carsten K. Nielsen, Maree T. Smith, Dianne Alewood, Paul F. Alewood and Richard J. Lewis
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2008
Development of Xen2174 - a Novel χ-Conopeptide Inhibitors of the Norepinephrine Transporter with Analgesic Potential
Authors: Elka Palant, Richard J. Lewis, Andreas Brust, Barbara Colless, Peter Schmidt, Stuart Gibbons, Rober Geckeler, Wendy Martin, Roger Drinkwater
Click here to view poster presented at the Australian Health and Medical Research Congress, Brisbane, 16-21 November 2008
Development of Novel χ-Conopeptide Inhibitors of the Norepinephrine Transporter with Analgesic Potential
Authors: Richard J. Lewis, Elka Palant, Andreas Brust, Barbara Colless, Peter Schmidt, Carsten Nielson, Maree Smith, Roger Drinkwater, Affiliations: Xenome Ltd, Brisbane, Queensland, Australia; Department of Pharmacy, University of Queensland, Australia
Click here to view poster presented at the 12th World Congress of Pain, Glasgow 17-22 Aug 2008
A Phase II Open Label, Single-Blind, Multicenter, Single-Dose, Dose-Escalating Safety and Tolerability Study of Intrathecal Xen2174 in Oncology Patients
Author: Dr Lisa Stearns, Xenome Pain Study Group: Prof. Michael Cousins, Dr Roger Gouke, Dr Tom Hughes, Dr Richard Rauck, Dr Miles Day, Dr Wendy Martin. Affiliations: Valley Cancer Pain Treatment Center, Scottsdale, AZ, USA; Centre for Anaesthesia and Pain Management Research, Royal North Shore Hospital, St Leonards, NSW, Australia; Department of Pain and Medicine, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; California Clinical Research, Inc., Davis, CA, USA; Center for Clinical Research, Winston-Salem, NC, USA; 6Anesthesiology/Pain Center, Texas Tech University Health Sciences Center, Lubbock, TX, USA, Xenome Inc., San Diego, CA, USA
Click here to view poster presented at the 12th World Congress of Pain, Glasgow 17-22 Aug 2008
Neuronally selective m-conotoxins from Conus striatus utlise an a-helical motif to target mammalian sodium channels.
Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan M, Thomas L,Adams DJ, Alewood PF and Lewis RJ (2008) J Biol Chem (epub June 2008).
Click here to view abstract
Conopressin-T from Conus tulipa Reveals an Antagonist Switch in Vasopressin-like Peptides
Sebastien Dutertre, Daniel Croker, Norelle L. Daly, Åsa Andersson,Markus Muttenthaler, Natalie G. Lumsden, David J. Craik, Paul F.Alewood, Gilles Guillon, and Richard J. Lewis
The Journal of Biological Chemistry 2008 Mar; 283(11):7100–710
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2007
High-Threshold Mechanosensitive Ion Channels Blocked by a Novel Conopeptide Mediate Pressure-Evoked Pain
Drew L, Rugiero F, Cesare P, Gale J, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis R, Wood J.
PloS ONE 2007 Jun; 2(6): e515
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Isolation and structure-activity of mu-conotoxin TIIIA, a potentinhibitor of tetrodotoxin-sensitive voltage-gated sodium channels.
Mol Pharmacol. 2007 Mar;71(3):676-85.
Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L, Adams
DA, Drinkwater R, Adams DJ, Alewood PF.
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High-throughput synthesis of conopeptides: a safety-catch linker approach enabling disulfide formation in 96-well format.
Brust A, Tickle A
J Pept Sci. 2007 Feb; 13(2): 133-141
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2006
Taxonomy of Australian Funnel-web spiders using rp-HPLC/ESI-MS profiling techniques
Wilson D, Alewood PF.
Toxicon. 2006 May;47(6):614-27. Epub 2006 Mar 22.
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2005
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain.
Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patteson M, Yaksh TL, McCumber D, Smith MT.
Pain. 2005 Nov; 118(1-2): 112-124
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Differential antagonism by conotoxin rho-TIA of contractionsmediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens,spleen and aorta.
Lima V, Mueller A, Kamikihara SY, Raymundi V, Alewood D, Lewis RJ, Chen Z, Minneman KP, Pupo AS.
Eur J Pharmacol. 2005 Jan 31;508(1-3):183-92
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Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
Obata H, Conklin D and Eisenach JC.
Pain. 2005 Feb;113(3):271-6.
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Were arachnids the first to use combinatorial peptide libraries?
Sollod BL, Wilson D, Zhaxybayeva O, Gogarten JP, Drinkwater R, and King GF
Peptides. 2005 Jan;26(1):131-9
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2004
Subtype-selective allosteric or competitive inhibition of human alpha-1-adrenergic receptors by rho-T1A
Chen Z, Rogge G, Hague C, Alewood D, Colless B, Lewis R, and Minneman K
Journal of Biological Chemistry 2004 Aug; 279(34):35326 - 33
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Biodiscovery - from reef to outback
Blake D
Nature Jun 2004; 429(Supp):A15-A17
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The State of Ion Channel Research in 2004
Ashcroft F, Benos D, Bezanilla F, Chien K, Choe S, Clapham D, Dougherty D, Lazdunski M, Levitan I, Lewis R, Liss B, Lummis S, Miller C, North A, Peters J, Sanguinetti M, Smart T, St•hmer W, Vandenberg J and Verkman A
Nature Reviews Drug Discovery 2004 Mar; 3(3):239-278
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2003
Therapeutic potential of venom peptides
Lewis RJ and Garcia ML
Nature Reviews Drug Discovery 2003 Oct; 2(10):790-802
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Inhibition of the norepinephrine transporter by the venom peptidechi-MrIA. Site of action, Na+ dependence, and structure-activityrelationship.
Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, and Lewis RJ.
Journal of Biological Chemistry 2003 Oct; 278(41):40317-23
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Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-T1A
Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, and Lewis RJ.
Journal of Biological Chemistry 2003 Sep; 278(36):34451-7
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2001
Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter
Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, and Lewis RJ.
Nature Neuroscience 2001 Sep; 4(9):902-7
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